Pittsburgh Pirates (38-50, fifth in the NL Central) vs. Seattle Mariners (45-42, second in the AL West)
Houston Astros (52-35, first in the AL West) vs. Los Angeles Dodgers (56-32, first in the NL West)
Los Angeles Angels (43-43, third in the AL West) vs. Toronto Blue Jays (49-38, first in the AL East)
Boston Red Sox (43-45, fourth in the AL East) vs. Washington Nationals (37-50, fifth in the NL East)
Cincinnati Reds (45-42, fourth in the NL Central) vs. Philadelphia Phillies (51-36, first in the NL East)
Milwaukee Brewers (48-39, second in the NL Central) vs. Miami Marlins (39-46, third in the NL East)
Chicago White Sox (28-59, fifth in the AL Central) vs. Colorado Rockies (20-67, fifth in the NL West)
Texas Rangers (43-44, fourth in the AL West) vs. San Diego Padres (46-40, second in the NL West)
Baltimore Orioles (37-49, fifth in the AL East) vs. Atlanta Braves (39-47, fourth in the NL East)
St. Louis Cardinals (47-41, third in the NL Central) vs. Chicago Cubs (52-35, first in the NL Central)