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Given the Rockies’ all-too-familiar failure to hit in the clutch, they looked doomed. They were.

And so it goes for the Rockies, who lost, 10-3, to the White Sox on Saturday night at Coors Field in front of a fireworks crowd of 47,351.

Colorado, 20-69, fell to 9-36 at home and has now lost all 15 home series this season. The White Sox, the majors’ worst road team, won the series opener on Friday night, 3-2.

Marquez, who had been on a nice run until Saturday’s game, didn’t pitch well. But then, he didn’t receive much offensive support. Colorado went 2 for 10 with runners in scoring position after opening the night 2 for 2 in clutch.

Colorado’s fifth-inning at-bat was a snapshot of frustration. Rookie right fielder Yanquiel Fernandez led off with a single to right and advanced to third on a double by hot-hitting right fielder Tyler Freeman. Second and third, nobody out, and the Rockies were in business.

But they couldn’t cash in. Hunter Goodman lined out to second, Jordan Beck flew out to second, and Thairo Estrada grounded out to short.

Colorado’s seventh inning was a facsimile of the fifth. It had the bases packed with nobody out, but Chicago reliever Jordan Leasure struck out Beck with a slider in a nine-pitch at-bat, and Thairo Estrada grounded to third baseman Josh Rojas, who started an inning-ending double play.

Early on, Colorado’s offense looked primed to bust out against right-hander Jonathan Cannon. Freeman led off the first with a single, extending his career-high on-base streak to 20 games. Goodman followed with a double, and Beck drove them both home with a bloop single to right, tying the game at 2-all.

Yet, despite several scoring opportunities, Cannon held Colorado in check for the rest of his start. Over 5 1/3 innings, he gave up eight hits, but just two runs, walking two and striking out one.

Marquez entered the night on a roll. He had a 2.70 ERA with 40 strikeouts over his last eight starts. But the White Sox hit him hard and often. In a two-run first, Sosa — who had a career-high four RBIs — hit a one-out double. Brooks Baldwin drove in Sosa with a two-out double to right, and rookie shortstop Colson Montgomery drove in Baldwin with a triple to right.

Marquez (3-10, 5.62 ERA) gave up 11 hits, walked one, and struck out two.

One ray of light for Colorado was a leadoff, pinch-hit homer in the eighth by Brenton Doyle.

The White Sox had 15 hits, topped off by Michael A. Taylor’s two-run homer off lefty reliever Ryan Rolison in the ninth.

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